In the research unit, we investigate relationships between macro-circulation and micro-circulation in term and preterm neonates. Macro-circulation describes the heart function and circulation in the large vessels and micro-circulation describes blood flow and oxygen saturation in the small vessels in the tissue. Measurements are carried out using non-invasive methods that do not injure the skin. Besides the brain also the muscle tissue is investigated with the focus on whether early changes of micro-circulation that occur in diseases can be detected and can help to guide therapies.